CACHE

CRITICAL ASSESSMENT OF COMPUTATIONAL HIT-FINDING EXPERIMENTS

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Join the CACHE Challenges!

Calling all computational chemists and artificial intelligence (AI)-savvy scientists from academia, biotech and pharma to participate in the CACHE Challenges to predict small molecules (hits) that bind to disease-associated protein targets.

Each CACHE Challenge will focus on a specific protein target of biological or pharmaceutical relevance. Participants will predict hits and CACHE will validate these hits experimentally. Each competition includes a hit-finding and a hit expansion round of prediction and experimental testing after which all data, including chemical structures, will be made publicly available without restrictions on use.

 

To be added to our mailing list and keep up-to-date with CACHE, send an email to cachenews@thesgc.org

Challenge #1

cache challenge PREDICT HITS FOR THE WDR DOMAIN OF LRRK2

PREDICT HITS FOR THE WDR DOMAIN OF LRRK2

Predict hits for the WD40 repeat (WDR) domain of LRRK2, a Parkinson's Disease target.

LRRK2 is the most commonly mutated gene in familial Parkinson's Disease. 

More details are shared in the data package on the Competition #1 page.

Last date to apply is 2022-01-31

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